Effects of Propylene Glycol 1,2-Dinitrate on Rhesus Monkey Visual Evoked Response and Sidman Avoidance Task
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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Two rhesus monkeys Macaca mulatta were exposed to propylene glycol 1,2-dinitrate PGDN vapors for 4 hours at concentrations ranging from 2 ppm to 33 ppm. Visual evoked response and Sidman avoidance task data were collected after 2 hours and 4 hours of exposure. Performance on the Sidman avoidance task was not affected at any dose level. The only component of the visual evoked response which PGDN affected was the late positive 100-500 msec wave, which increased 20 percent at 2 ppm and decreased 25 percent at concentrations up to 33 ppm. It was possible to reverse the effect at 33 ppm by altering tension on the monkeys Sidman response lever this raises the question of specificity of visual evoked response to PGDN. Because of the reversibility of the effect, and since the changes occurred at a latency and amplitude consistent with those expected from the aversive, distracting properties of the vapor, the visual evoked response changes could not be unambiguously attributed to neurotoxic changes in the central nervous system.