Accession Number:

ADA023486

Title:

Chemotherapy of Malaria

Descriptive Note:

Annual rept. no. 4, 1 Jun 1969-31 May 1970

Corporate Author:

MIAMI UNIV FL

Personal Author(s):

Report Date:

1970-05-31

Pagination or Media Count:

25.0

Abstract:

Some 22,376 compounds were screened for antimalarial activity in the period from June 1, 1969 through May 31, 1970. Tables 1, 2, 3, 4, 5, and 6 list, month by month, the number of compounds tested and the number of mice used from June 1, 1964 through May 31, 1970. Table 7 is a summary of the total number of compounds screened from the inception of this program to date. Of the 22,376 compounds tested from June 1, 1969 through May 31, 1970 over 1066 demonstrated a degree of antimalarial activity sufficient to produce at least 100 increases in the survival time of treated Plasmodium berghei infected mice. A simple but dependable supplementary test with Plasmodium gallinaceum malaria in chicks has been developed. 26,049 compounds were screened for antimalarial activity in the period from June 1 1969 through May 31, 1970. Tables 8, 9, 10, 11, 12, and 13 list, month by month, the number of compounds tested and the number of chicks used from January, 1965 through May 31, 1970. Table 14 summarizes the number of compounds tested and the number of chicks used from the inception of this assay system in January, 1965 to date. Of the 26,049 compounds tested in chicks from June 1, 1969 to May 31, 1970, over 262 demonstrated a degree of antimalarial activity that produced a minimum of 100 increase in the survival time of Plasmodium gallinaceum infected chicks.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE