Hazard Evaluation of Candidate Deer Fly Repellent AI3-70087, 2-Hydroxyethyl Cyclohexanecarboxylate.
Final rept. Sep 74-Oct 75,
ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
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A hazard evaluation of the candidate deer fly repellent 2-hydroxyethyl cyclohexanecarboxylate AI3-70087 was performed by means of laboratory animal studies using rats, rabbits, guinea pigs and dogs, and in vitro studies using bacteria, yeast and mouse lymphoma cells. The technical grade compound did not produce primary irritation when applied to the intact or abraded skin of rabbits. Daily application of AI3-70087, as a 10 percent solution in ethyl alcohol to the intact skin of rabbits for 15 days, produced no deleterious local skin effects. Mild injury to the cornea and slight chemosis, redness and discharge of the conjunctiva, resulted from single application to the eyes of rabbits. Data indicated that this compound may be harmful if accidentally swallowed. The compound did not produce a skin sensitization reaction in guinea pigs or a photochemical skin irritation reaction in rabbits. Studies of percutaneous penetration using C14 labeled compound indicated that this material is absorbed through the skin of rabbits and dogs, and is partially excreted in the urine. An in vitro mutagenic evaluation of AI3-70087 was inconclusive.