Chemotherapy of Rodent Malaria Drug Action Against Exo-Erythrocytic Stages and Drug Resistant Strains.
Final rept. Oct 74-Oct 75,
LIVERPOOL SCHOOL OF TROPICAL MEDICINE (ENGLAND) DEPT OF PARASITOLOGY
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Data were provided on the blood schizontocidal activity of one WRAIR compound and the causal prophylactic activity of 25 compounds, emphasis again being laid on a detailed evaluation of the latter. Most of the causal prophylactics tested have been in the 8-aminoquinoline series. A comparison of the rodent and simian models is presented below. Attention has been paid in particular to long-term studies designed to follow the inhibitory effect of drug mixtures on the emergence of drug resistance and its prevention. A sulphonamide was found to inhibit the development of resistance to WR 142,490 mefloquine. Further studies were carried out on the modes of action of various compounds including mepacrine, chloroquine, quinine and new WRAIR compounds with quinine-type action. Minocycline and erythromycin have also been investigated further.