Investigation on Pathogenesis and Therapy of Compound Injuries,
ARMY MEDICAL INTELLIGENCE AND INFORMATION AGENCY WASHINGTON D C
Pagination or Media Count:
It has been shown in previous investigations that irradiation of NMRI-mice induced profound changes in the protein composition of blood serum, when an additional open skin wound was inflicted on the animals after irradiation. The degree of change, i.e., decrease of albumin and alpha-1-globulin levels and increase of the alpha-2- and betaglobulin levels is clearly correlated with lethality. If the skin lesions are sewed up 15 minutes or 3 hours after operation, however, the serum protein changes are not so distinct and mortality declines. Based on these results it is postulated that the protein albumin loss with tissue fluids from wounds is greater if the organism was irradiated previously The increase of the alpha-2- and betaglobulins could be a compensatory mechanism of balancing protein loss and to normalize the fluid qualities of serum.