Dopamine Depolarizing Response in a Vertebrate Neuronal Somatic Cell Hybrid.
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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The response to iontophoretically applied dopamine was studied in the somatic cell hybrid 108CC15. Dopamine gave a depolarizing response with a conductance increase. The reversal potential for the response was -15.9 mV. Known dopamine antagonists blocked the response. These results demonstrate a dopamine response in a single cell preparation of vertebrate neuronal origin and the utilization of cultured cells to study receptor mechanisms in an isolated, controlled environment. Author