Accession Number:

ADA022072

Title:

Dopamine Depolarizing Response in a Vertebrate Neuronal Somatic Cell Hybrid.

Descriptive Note:

Scientific rept.,

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Personal Author(s):

• Myers,P. R.
• Livengood,D. R.

Report Date:

1975-12-01

Pagination or Media Count:

14.0

Abstract:

The response to iontophoretically applied dopamine was studied in the somatic cell hybrid 108CC15. Dopamine gave a depolarizing response with a conductance increase. The reversal potential for the response was -15.9 mV. Known dopamine antagonists blocked the response. These results demonstrate a dopamine response in a single cell preparation of vertebrate neuronal origin and the utilization of cultured cells to study receptor mechanisms in an isolated, controlled environment. Author

Descriptors:

• *DOPAMINE
• *NERVE TRANSMISSION
• DEPOLARIZATION
• HYBRID SYSTEMS
• NERVE CELLS
• RESPONSE(BIOLOGY)
• CELLS(BIOLOGY)
• CULTURES(BIOLOGY)
• CHEMORECEPTORS

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE