Accession Number:

ADA021681

Title:

Behavioral and Biochemical Effects of 4-Benzothienyl-N-Methylcarbamate (MOBAM, Trade Mark).

Descriptive Note:

Special study rept. Jun-Sep 75,

Corporate Author:

ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD

Personal Author(s):

Report Date:

1975-01-01

Pagination or Media Count:

19.0

Abstract:

Decreases in rat plasma, erythrocyte and brain cholinesterase levels after intraperitoneal injection of 1 to 5 mgkg of 4-benzothienyl-N-methylcarbamate MOBAM, were compared with decrements in spontaneous motor activity and changes in performance of a rapidly acquired conditioned avoidance response produced by this compound. Significant effects were observed with all five measures at dosages producing no obvious clinical signs. A dosage of 2 mgkg significantly depressed plasma and erythrocyte cholinesterase activity and decreased motor activity 15 minutes after injection. Higher dosages 2.5 to 5 mgkg significantly depressed brain cholinesterase activity and avoidance performance.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE