Malaria Immunity: Cell-Mediated Studies.
Rept. no. 8 (Final), Oct 73-Dec 75,
LOWELL UNIV RESEARCH FOUNDATION MASS
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The authors were able to effect recovery and immunity to virulent murine malaria by red cell transfusion at crisis, during which time erythropoiesis did not keep pace with the rate of red cell destruction. Utilizing these immune animals as a source of spleen cells the authors have demonstrated by in vitro techniques the presence of two cell-mediated cytotoxic effector systems macrophages and lymphocytes against erythrocyte targets from malaria infected animals. Although parasitized erythrocytes appeared to be the most likely targets for cell-mediated destruction, decreased survival of transfused normal erythrocytes in malaria infected rats was observed. It has been further noted that splenic lymphocytes become specifically sensitized to malaria antigens during the course of virulent murine malaria infection, and have the ability to inhibit the migration of peritoneal macrophages in vitro Coleman, et al., 1975a.
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