Brain Amines in Drug Addiction.
Final rept. no. 1, 5 Jan 72-31 Mar 74,
HAHNEMANN MEDICAL COLL AND HOSPITAL PHILADELPHIA PA DEPT OF PHYSIOLOGY AND BIOPHYSICS
Pagination or Media Count:
Young animals were addicted over a period of seven days. Addiction was tested in selected animals with administration of naloxone demonstrating the typical withdrawal symptoms. Catecholamines CA were examined in specific regions of the brain by chemical analysis and fluorescence histochemistry. No significant changes were found in norepinephrine NE levels in the medulla, pons, cerebellum or various parts of the cerebral cortex. NE levels were markedly increased in the hypothalamus and the cingulate cortex during addiction. In control animals, fine CA varicosities were found histochemically along the ventral margin of the cingulate cortex adjacent to the corpus callosum. These have not been described previously. In addicted animals similar varicosities were found distributed throughout the cingulate cortex with highest localization in the ventromedial regions. In addicted animals CA fluorescence was decreased in certain regions of the hypothalamus and in the cerebral vasculature. In addition to the hypothalamic changes NE fibers in the cingulate cortex may play a significant role in opiate addiction. Author