Accession Number:

ADA018992

Title:

Measurement of Antifolate Drugs by Microbiological Assay.

Descriptive Note:

Annual rept. no. 2, 1 Jul 74-30 Jun 75,

Corporate Author:

CINCINNATI UNIV OHIO DEPT OF ENVIRONMENTAL HEALTH

Personal Author(s):

Report Date:

1975-12-15

Pagination or Media Count:

71.0

Abstract:

Contents Interim report no. 10 -- Measurement of antifolate drug levels by microbiological assay. Plasma levels of 4,6-diamino-1-2,4,5-trichloro-phenoxypropyloxy- 1,2-dihydro-2,2-dimethyl-s-triazine WR-99,210 Interim report no. 11 -- Measurement of antifolate drugs by microbiological assay. Plasma levels of 2,4-diamino-6-2-naphthyl-sulfonylquinazoline WR-158,122 in 11 human subjects given combinations of WR-158,122 and sulfadiazine. Interim report no. 12 -- Measurement of antifolate drugs by microbiological assay. Plasma levels of 1-2-4,5-trichlorophenoxy-propyloxy-1,2-dihydro-2,2-dimethyl-s-triazine WR-99,210 in 8 human subjects given single oral doses of 50 or 250 mg.

Subject Categories:

  • Microbiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE