Genetics of Novel Hybrid Bacteriophage and Development of Generalized Transducing System for 'Salmonella typhosa'.
Annual progress rept. no. 1, 1 Jan-31 Dec 75,
TEMPLE UNIV PHILADELPHIA PA SCHOOL OF MEDICINE
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Various hybrid phages between coliphage and Salmonella phage were isolated using bacterial hybrids between E. coli and Salmonella typhimurium. These hybrid phage species were genetically mapped for homology with their parental phages. The role of various parental phage genes of hybrid phages for their replication in S. typhimurium, E. coli-S. typhosa hybrid and E. coli was carefully analyzed. Essential bacterial and viral functions for replication of the hybrid phages in these bacterial strains provided important information for the process of viral infection. The P22-lamda hybrids have capabilities for antigen conversion and generalized transduction in both S. typhimurium and E. coli-S. typhimurium hybrid.