Accession Number:

ADA018833

Title:

Rifampin Concentrations in Cerebrospinal Fluid of Patients with Tuberculous Meningitis

Descriptive Note:

Technical scientific rept.

Corporate Author:

NAVAL MEDICAL RESEARCH UNIT NO 3 FPO NEW YORK 09527

Personal Author(s):

• Sippel, John E.
• Mikhail, Isis A.
• Girgis, Nabil I.
• Youssef, Hassan H.

Report Date:

1973-11-16

Pagination or Media Count:

6.0

Abstract:

Rifampin was administered orally in one dose of 25 mg per kg of body weight to 6 patients with tuberculous meningitis who had received no previous antituberculous chemotherapy and to 7 control subjects. There was no sigificant difference in rifampin absorption at 3 hours between patients and control subjects however, no rifampin could be detected in the 3-hour cerebrospinal fluid CSF specimens taken from control subjects. Significant concentrations were reached in patients CSF within 3 hours and were maintained for 24 hours.

Descriptors:

• *TUBERCULOSIS
• *CEREBROSPINAL FLUID
• *MENINGITIS
• *CEREBROSPINAL MENINGITIS
• REPRINTS
• EGYPT
• LEVEL(QUANTITY)
• ABSORPTION
• CHEMOTHERAPY
• INGESTION(PHYSIOLOGY)
• BLOOD ANALYSIS
• BIOASSAY
• DRUGS
• BLOOD SERUM
• CHEMICAL ANALYSIS
• CONCENTRATION(CHEMISTRY)

Subject Categories:

• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE