Rifampin Concentrations in Cerebrospinal Fluid of Patients with Tuberculous Meningitis
Technical scientific rept.
NAVAL MEDICAL RESEARCH UNIT NO 3 FPO NEW YORK 09527
Pagination or Media Count:
Rifampin was administered orally in one dose of 25 mg per kg of body weight to 6 patients with tuberculous meningitis who had received no previous antituberculous chemotherapy and to 7 control subjects. There was no sigificant difference in rifampin absorption at 3 hours between patients and control subjects however, no rifampin could be detected in the 3-hour cerebrospinal fluid CSF specimens taken from control subjects. Significant concentrations were reached in patients CSF within 3 hours and were maintained for 24 hours.
- Medicine and Medical Research