Accession Number:

ADA018833

Title:

Rifampin Concentrations in Cerebrospinal Fluid of Patients with Tuberculous Meningitis

Descriptive Note:

Technical scientific rept.

Corporate Author:

NAVAL MEDICAL RESEARCH UNIT NO 3 FPO NEW YORK 09527

Report Date:

1973-11-16

Pagination or Media Count:

6.0

Abstract:

Rifampin was administered orally in one dose of 25 mg per kg of body weight to 6 patients with tuberculous meningitis who had received no previous antituberculous chemotherapy and to 7 control subjects. There was no sigificant difference in rifampin absorption at 3 hours between patients and control subjects however, no rifampin could be detected in the 3-hour cerebrospinal fluid CSF specimens taken from control subjects. Significant concentrations were reached in patients CSF within 3 hours and were maintained for 24 hours.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE