Syphilis Vaccine and Immune Mechanisms.
Annual rept. no. 4, 1 Jan-31 Dec 75,
CALIFORNIA UNIV LOS ANGELES DEPT OF MEDICAL MICROBIOLOGY AND IMMUNOLOGY
Pagination or Media Count:
Development of an Effective and Practical Vaccine Against Experimental and Human Syphilis. No immunity to the intradermal challenge of 500 T. pallidum was demonstrated among rabbits vaccinated intramuscularly at 4-week intervals with a total of 4 vaccine doses, each containing an equal volume of approx. 4 x 10 to the 9th power gamma irradiated 1,000,000 rads, liquid-nitrogen preserved T. pallidum and an alginate-gluconate adjuvant each of the vaccinated animals developed VDRL and FTA-ABS antibodies, while none developed TPI antibody nor exhibited an anamnestic response following challenge. The possibility that irradiation with 1,000,000 rads damages the immunogens responsible for stimulating host-resistance, has led to the design of experiments in which T. pallidum gamma-irradiated with 650,000 rads will be utilized in the protocol described above in an effort to achieve a clearly demonstrable complete immunity. Author
- Medicine and Medical Research