Accession Number:

ADA018539

Title:

Investigation of the Method of Aerosol Immunization with Powder Plague Vaccine on Wide Contingents of People

Descriptive Note:

Corporate Author:

FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSONAFB OH

Report Date:

1975-11-25

Pagination or Media Count:

16.0

Abstract:

Single aerosol immunization of people with powder plague vaccine was accompanied by a weak general reaction. Double aerosol vaccination of people, carried out with a short interval between innoculations 5 days, was characterized by a somewhat higher reaction compared with the single vaccination. The reaction was significantly less pronounced than with a subcutaneous vaccination. The epictutaneous method of immunization, with respect to number and intensity of general reactions, corresponded to the single aerosol, but with respect to local reactogenicity it significantly exceeded the aerosol. The most pronounced sero-allergic shifts were noted in those persons who were innoculated twice in addition the immunological effectiveness of the aerosol method of vaccination corresponded to the immunological effectiveness of the subcutaneous method. The immunological effectiveness of the single and double epicutaneous immunization is lower than the aerosol and subcutaneous. A further and more in-depth comparative study should be made of the ractogenicity and immunological effectiveness of the aerosol, subcutaneous and epicutaneous methods of immunization against plague.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE