Exploratory Development to Study the Long-Term Effects of Resorbable Ceramics in Primates.
Final rept. 1 May 72-30 Jun 75,
DAYTON UNIV OHIO RESEARCH INST
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The objective of the program was to study the suitability and long-term effect of resorbable ceramic implants as bone gap bridges in Rhesus monkeys. The long-range goal of the work of this type is to demonstrate the feasibility of long bone repair in humans using resorbable ceramic implants. The ceramics used as implants were porous calcium aluminates with phosphorus pentoxide additions. A total of eight implantations were accomplished, five of the implanted animals had to be sacrificed permanently due to problems not the fault of the implants. Implants were 20 mm. in diameter by 25 mm. long and were in place 24-29 months. Examination of the implants using a scanning electron microscope revealed that the composition and resulting pore structure did not encourage manualized bone ingrowth. Short term implant studies have since shown that an increased amount of P2O5 20 and a pore size of 60-80 micrometers provides the optimum amount of resorption and bone ingrowth.
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