Dermal Penetration of Radio-Labeled Topical Repellents Cyclohexamethylene Carbamide and n-Butylsulfonimido cyclohexamethylene.
Special study Aug 74-Feb 75,
ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
Pagination or Media Count:
The percutaneous absorption of radio-labeled topical insect repellents cyclohexamethylene carbamide and n-butylsulfonimidocyclohexamethyelen was determined following application to the intact skin of rabbits. Urine excretion of cyclohexamethylene carbamide was 64.9 percent of applied dose after seven days. n-Butylsulfonimidocyclohexamethylene excreted in the urine was 48.4 percent of applied dose after seven days. Only trace quantities of labeled repellents were found in tissue specimens of rabbits monitored seven days after topical application.