Accession Number:

ADA017131

Title:

Inhibition of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase by Chlorpromazine.

Descriptive Note:

Technical rept. Jun 74-Feb 75,

Corporate Author:

EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s):

Report Date:

1975-10-01

Pagination or Media Count:

10.0

Abstract:

Chlorpromazine CPZ protects rabbits against anticholinesterase poisoning, while cyclic adenosine 3,5-monophosphate cAMP potentiates the toxicity of anticholinesterase compounds. Chlorpromazine is shown to be a noncompetitive inhibitor of cAMP activation of cAMP-dependent protein kinase PK. The metabolic and pharmacological consequences of CPZ inhibition of PK and its possible relationship to protection against anticholinesterase agents are discussed.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE