Inhibition of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase by Chlorpromazine.
Technical rept. Jun 74-Feb 75,
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
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Chlorpromazine CPZ protects rabbits against anticholinesterase poisoning, while cyclic adenosine 3,5-monophosphate cAMP potentiates the toxicity of anticholinesterase compounds. Chlorpromazine is shown to be a noncompetitive inhibitor of cAMP activation of cAMP-dependent protein kinase PK. The metabolic and pharmacological consequences of CPZ inhibition of PK and its possible relationship to protection against anticholinesterase agents are discussed.