Effects of Monomethylhydrazine on Thalamocortical Excitability and Patterns of Sleep in the Cat
CALIFORNIA UNIV LOS ANGELES SCHOOL OF MEDICINE
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The influence of subconvulsive exposure was examined with reference to a more basic aspect of physiological function than previous sensorimotor and performance studies namely, the organization of sleep-waking patterns. Polygraphic recordings providing for classification of states of sleep and wakefulness were obtained over a 10-hr period following either saline or MMH 5mgkg, IP injections. MMH caused no overt behavioral disruption on transient observation at this dose however, analysis of polygraphic data disclosed a significant depression of sleep and disruption of normal diurnal rhythms. Sleep suppression lasted approximately 6 hours and was followed by a profound sleep rebound. The behavioral effects of MMH exposure extended beyond the realm of sensorimotor functions. The influence noted upon sleep could have equally serious and different consequences in performance. In a second study the effect of MMH upon thalamocortical conduction was examined.
- Anatomy and Physiology
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