The Extinction of Pavlovian Elicited Conditional Morphine Reactions.
Final comprehensive rept. 1 Oct 72-1 Jul 74,
MARYLAND UNIV BALTIMORE DEPT OF PSYCHIATRY AND PHYSIOLOGY
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A classical Pavlovian conditioning paradigm has been developed wherein small intravenous infusions of morphine paired with a tone have been shown to rapidly form conditional heart rate and salivary responses in dogs and conditioned heart rate, EEG and evoked potential response in rats. In dogs, these morphine conditioned responses CRs were elicited after as little as five pairings and were subsequently highly resistant to daily extinction trials over a three month period. Naloxon produced intense withdrawal reactions in dogs drug free for several months. Although profound uunconditioned responses UCRs are formed to very small doses of morphine, no CRs appeared until larger doses were administered. Diphenylhydantoin has been shown to be an effective agent in blocking both signs of withdrawal in addicted rats and morphine induced mania in cats and may play an important role in modifying Pavlovian conditioning reactions to morphine.
- Anatomy and Physiology