Mechanisms of Amizyl (Benactyzine) and Diphacil Action on the Brain
ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER CHARLOTTESVILLE VA
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Proof is presented that amizyl and diphacil may only block the central choline receptors, but have an effect on the presynaptic reservoirs of mediators. Amizyl releases noradrenalin from the synaptic vesicles. Diphacil stabilizes the presynaptic reservoirs of catecholamines, nicotine releases noradrenalin and, apparently, dopamine from the presynaptic reservoirs. It is proposed that the basis of action of nicotine on the brain is release of catecholamines from their presynaptic reservoirs and that central n- cholinolytics prevent this action of nicotine.