Blood Lipid Responses to Decompression Sickness
Rept. no. 1 (Final)
NORTH TEXAS STATE UNIV DENTON DEPT OF CHEMISTRY
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Studies were conducted to determine the role of circulating lipids in the etiology of decompression sickness and to evaluate liver and adipose tissues as possible sources of embolic lipid. It was found in in vitro studies with rat liver slices that pressurization alone may be an inadequate stimulus for initiation of excessive liver lipid biosynthesis, and that an inadequate decompression may not result in a significant lipid loss from liver and adipose tissue. In vivo experiments were performed employing various agents known to affect various aspects of lipid metabolism. These agents were administered to rats which were subsequently exposed to a pressurization profile. The implications from this study were 1 The levels of circulating lipids have little effect on decompression sickness. 2 circulating free fatty acids have a profound effect on decompression sickness. 3 ionic calcium concentrations are possibly involved in the etiology of decompression sickness.
- Stress Physiology