Initial Slope Index of Total Cerebral Blood Flow Measured by Hydrogen Clearance: A Pragmatic Evaluation
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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An initial slope index of total cerebral blood flow, measured by hydrogen clearance from torcular blood, shows high correlation with flows calculated by bicompartmental analysis. In 247 flow measurements done on 41 rhesus monkeys, a linear regression analysis between these two methods of calculating flow shows a correlation coefficient of 0.9280 with a standard error about y values of plus or minus 7.63. The initial slope index is not only faster to calculate but does not require that a steady state be maintained for 10 minutes.
- Anatomy and Physiology