Accession Number:

ADA012357

Title:

Effects of Alpha0Methyltyrosine and 5-Fluorouracil on Astrocyte Density in the Rat Spinal Cord Dorsal Funiculi after Stab-would Lesion.

Descriptive Note:

Annual rept. no. 2, 1 Jun 73-31 May 74,

Corporate Author:

NORTHERN ARIZONA UNIV FLAGSTAFF DEPT OF BIOLOGICAL SCIENCE

Personal Author(s):

Report Date:

1975-01-30

Pagination or Media Count:

11.0

Abstract:

Rats were lesioned by a stab wound in the mid-thoracic spinal cord. Chemotherapy with alpha methyl-tyrosine AMT followed shortly. This represented an attempt to reduce the concentration of noreprenephrine which causes hemorrhage and subsequent necrosis of cells of the central nervous system. This was followed by determining the extent of post-trauma gliosis astrocyte density. The AMT treated cord has an average astrocyte density that is 11.1 greater than the control lesion and no chemotherapy. However, this difference was not statistically significant.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE