Accession Number:

ADA012239

Title:

The Role of Inorganic Phosphate in Oxygen Transport.

Descriptive Note:

Annual progress rept. 1973-1974,

Corporate Author:

CALIFORNIA UNIV SAN FRANCISCO

Personal Author(s):

Report Date:

1974-11-05

Pagination or Media Count:

29.0

Abstract:

The studies are concerned with the role of inorganic phosphate in the modulation of red cell glycolysis by the formation of 2,3 disphosphoglycerate and adenosine triphosphate and their interaction with the red cell in the recovery from massive transfusion. The thrust of these studies has attempted to delineate the importance of the half saturation point P50 of the oxyhemoglobin association curve, low levels of 2,3 diphosphoglycerate and adenosine triphosphate in blood of extended storage life and the role of inorganic phosphate in repletion. The data indicate that patients receiving 90 or more of their blood volume have wide ranges of inorganic phosphate variation while a small group of patients have very low inorganic phosphates which conceivably is due to its incorporation to the red cell. More patients have high levels of inorganic phosphates which may be considered a useful response and correlates well with the return of red cell phosphates.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE