Experimental Evaluation of Woven Polylactic Acid, Polyester Tubes as Trachael Prostheses.
Scientific rept. no. 3 (Final) 1 Aug 71-1 Jan 75,
LANKENAU HOSPITAL PHILADELPHIA PA
Pagination or Media Count:
Woven tubes of either polyester fibers or mixed polyester, polylactic acid fibers of appropriate sizes were prepared for substitution of the rabbit and dog trachea. Limited but significant survival of rabbits was achieved postimplantation using both types of woven tubes. Tissue acceptance of the woven tube prostheses was studied histologically after subcutaneous implantation in rabbits. Polylactic acid fibers were observed to increase in size and decrease in staining intensity early after implantation and finally disappear. Cellular reactivity and fibroplasia was greater in specimens containing polylactic acid fibers as compared with those containing polyester fibers. It is concluded from these experiments that a mechanically suitable prosthetic tube can be fabricated for tracheal substitution by weaving but that tissue healing with intraluminal epithelial resurfacing is inhibited by the occurrence of implant infection which results in lumen obstruction.
- Medical Facilities, Equipment and Supplies