Development of a Synthetic Polymer Burn Covering.
Progress rept. 1 Jan-1 Jun 75,
DYNATECH R/D CO CAMBRIDGE MASS
Pagination or Media Count:
Laboratory and preliminary in vivo burned rat model testing of a freeze-dried collagenpoly-caprolactone film laminate FDCPCL and a freeze-dried poly-caprolactone foampoly-caprolactone film laminate PCL foamfilm as wound coverings have been completed. Porcine skin has also been evaluated in vivo. The laminates are flexible and, when moistened, become somewhat transparent permitting observation of the wound. Early adherence of both coverings to the wound was realized. The force required to remove the PCL foamfilm laminate from a full thickness excision wound increased from 170 dynessq. cm. on the first day post graft to 1500 dynessq. cm. by the tenth day. The force required to remove FDCPCL laminates remained constant, 220 dynessq. cm., over the ten day test period. Insensible water loss rates from animals grafted with the laminates were similar to that from animals with human cadaver skin grafts. Color illustrations reproduced in black and white.
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