Accession Number:

ADA011868

Title:

Statistical Models for Estimating Carcinogenic Risks from Animal Data.

Descriptive Note:

Final rept.,

Corporate Author:

AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OHIO

Personal Author(s):

Report Date:

1974-12-01

Pagination or Media Count:

9.0

Abstract:

A problem of great concern currently faced by regulatory agencies is the prediction of carcinogenic risk of various environmental agents to man. Typically, a prediction of carcinogenic incidence in humans is required at a level of exposure considerably below experimental animal levels from which the predictions are derived. This presents two problems first, the statistical extrapolation to low-dose levels, and secondly, the mouse-to-man or species extrapolation. The statistical techniques used for low-dose extrapolation is briefly discussed in this paper.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE