The Effects of 6-Month Chronic Low Level Inhalation Exposures to Hydrazine on Animals
AIR FORCE AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH
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To compare the effects of repeated 6 hour per day, 5 day per week industrial type exposures with continuous exposures of equivalent concentrations and to evaluate the safety factor of the current threshold limit value TLV, four concentration levels were selected for the 26-week exposure of four animal species. The concentrations selected were 1.0 ppm and 0.2 ppm for continuous exposures and 5.0 ppm and 1.0 ppm for intermittent daily exposures. The effects of chronic inhalation of hydrazine are dose related regardless of the nature of exposure, i.e., intermittent or continuous. The highest hydrazine dose caused approximately 40 deaths in mice within the first two months of exposure while the TLV dose equivalents caused approximately 5 mortality.