Mechanisms of Carcinogenesis by Nitroso Compounds.
AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OHIO
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The formation of carcinogenic nitrosamines from amines and nitrites in the body has been demonstrated, and tumours have been induced by simultaneous administration of these materials to experimental animals. A number of drugs, pesticides and other environmental chemicals have secondary or tertiary amino structures and various amines occur in food. Nitrites are present in various vegetables and are added to certain foods as preservatives. Nitrates, which are found in drinking water, can be reduced to nitrites in the body and nitrites are present in human saliva. It is clear, therefore, that any amine in the stomach may be nitrosated, and perhaps give rise to a carcinogenic nitrosamine.