Accession Number:

ADA011858

Title:

Cardiophysiological Studies with Stressed Animals.

Descriptive Note:

Final rept.,

Corporate Author:

AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OHIO

Personal Author(s):

Report Date:

1974-12-01

Pagination or Media Count:

18.0

Abstract:

The report presents data that show trifluoro-chloromethane F-11 is more toxic to cardiomyopathic hamsters than to random-bred hamsters, and that the toxicity is qualitatively different as well. It was also shown in another species that the arrhymic potential of F-11 is increased by hypoxia and the arrhythmias observed are not the result of hypoxia alone. The data from these animal studies are not directly applicable to humans. Genetic cardiomyopathy is not presented as a model of human heart disease or even human cardiomyopathy. The acute hypoxia induced in rabbits is not representative of the acute hypoxic state of the patient with diseases such as asthma or respiratory failure. These data show only that animals with depressed physiologic reserve were more sensitive to F-11 than normal animals.

Subject Categories:

  • Stress Physiology
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE