Comments on a Plastics Industry Neurotoxicity in Relationship to Methybutyl Ketone
AIR FORCE AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH
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The purpose of these studies was to establish an animal model of peripheral neuropathy in order to demonstrate the etiologic relationship of a volatile solvent to this disease. The inhalational route was used, exposing animals in a modified germ-free apparatus fitted for flow-through concentrations of vapors carried via a continuous air flow. The study demonstrated that the continuous exposure of animals to MBK can produce leg weakness which progresses to a paralytic neuropathy in chickens, cats and rats, but not mice. Many clinical features of the peripheral neuropathy in the workers were also demonstrable in the animals, for example, muscle weakness, alterations in electromyogram, RBC and serum cholinesterase changes. The histologic changes in animals remain unknown for man since no nerve biopsies were obtained.
- Environmental Health and Safety