Gastric Secretory Response to Acute Isotonic Hypervolemia.
Medical research progress rept.,
NAVAL MEDICAL RESEARCH INST BETHESDA MD
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The effects of acute isotonic extracellular fluid volume expansion were studied in conditioned, anesthetized dogs who underwent pyloric ligation and creation of an external gastric fistula. A hypervolemic state was produced with intravenous Ringers lactate solution. The canine stomach responded as a third-kidney by significantly increasing gastric juice volume 528 per cent and gastric acid output 696 per cent. This occurred paradoxically in the presence of a lactate load and a metabolic alkalosis.
- Anatomy and Physiology
- Medicine and Medical Research