A Comparison of Asanguineous Fluids and Whole Blood in the Treatment of Hemorrhagic Shock.
Medical research progress rept.,
NAVAL MEDICAL RESEARCH INST BETHESDA MD
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The object of this comparative study was to evaluate the circulatory and Metabolic responses of baboons in a state of oligemic shock to treatment with 5 albumin in saline solution followed by shed red blood cells, or isotonic saline solution followed by shed red blood cells, or whole blood alone. Without treatment, the mortality for the baboons was 100. With treatment, the survival rates between the groups were not significantly different. The saline solution treatment group required 4.1 times the volume of shed blood, while the other groups required approximately 1.4 times the volume of shed blood. While there were some initial differences, by the end of the final resuscitation period, no significant differences were noted in cardiac output, pulmonary and peripheral vascular resistances, serum lactate, arteriovenous pO2 gradient difference, or arterial pressure.
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