Accession Number:

ADA010820

Title:

Aseptic Endotoxemia in Radiation Injury and Graft Versus Host Disease

Descriptive Note:

Scientific rept.,

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Personal Author(s):

• Walker, R. I.
• Ledney, G. D.
• Galley, C. B.

Report Date:

1975-02-01

Pagination or Media Count:

20.0

Abstract:

Endotoxemia of intestinal origin may impair physiologic and immunologic functions in individuals subjected to high doses of either ionizing radiation or radiation followed by transplants of foreign immune competent cells capable of producing graft versus host disease GVHD. The results of the following studies support the contention that aseptic endotoxemia may be due to failure to clear endotoxin from the circulation and detoxify it in the liver of immunosuppressed animals.

Descriptors:

• *IMMUNOSUPPRESSION
• *ENDOTOXINS
• *RADIATION INJURIES
• IMMUNOLOGY
• SEPSIS
• PHAGOCYTES
• SURGICAL TRANSPLANTATION
• RADIOBIOLOGY

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE