Aseptic Endotoxemia in Radiation Injury and Graft Versus Host Disease
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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Endotoxemia of intestinal origin may impair physiologic and immunologic functions in individuals subjected to high doses of either ionizing radiation or radiation followed by transplants of foreign immune competent cells capable of producing graft versus host disease GVHD. The results of the following studies support the contention that aseptic endotoxemia may be due to failure to clear endotoxin from the circulation and detoxify it in the liver of immunosuppressed animals.
- Medicine and Medical Research