Accession Number:

ADA010237

Title:

Effects of Immunodepression on Antibody Binding Affinity.

Descriptive Note:

Final rept. 1 Nov 71-1 Mar 75,

Corporate Author:

CORNELL UNIV MEDICAL COLL NEW YORK

Personal Author(s):

• Siskind,Gregory W.

Report Date:

1975-05-31

Pagination or Media Count:

48.0

Abstract:

There is a progressive increase in antibody affinity with time after immunization. Agents adjuvants which increase the magnitude of the immune response favor selection for high affinity antibody synthesis. Agents such as antigenic competition, cyclophosphamide, 6-mercaptopurine and anti-lymphocyte antiserum which nonspecifically depress the magnitude of the immune response tend to make selection for high affinity antibody synthesis proceed more slowly.

Descriptors:

• *ANTIBODIES
• *IMMUNOSUPPRESSION
• IMMUNITY
• CELLS(BIOLOGY)
• ANTIGENS
• BIOSYNTHESIS

Subject Categories:

• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE