Human Bioassay of Antimotion Sickness Drugs,
NAVAL AEROSPACE MEDICAL RESEARCH LAB PENSACOLA FL
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Great individual differences in response to antimotion sickness drugs administered in usual doses were revealed. In one experiment involving 11 subjects and 7 drugs the single best therapeutic response implicated all seven drugs tested three single drugs and four fixed-dose combinations. In terms of percentage of subjects demonstrating a substantial beneficial antimotion sickness drug effect, administration of a fixed-dose combination of promethazine hydrochloride and ephedrine sulfate 25 mg each proved to be outstanding this combination of homergic drugs clearly exhibited a suprasummation effect. A few tests were conducted using larger than usual doses and the results support previous findings that for a maximal beneficial effect in response to a single dose, individuals may vary both with regard to the choice of drug and the amount administered.