Accession Number:

ADA009792

Title:

Sorption and Retention of Substances in the Surface Layers of the Skin.

Descriptive Note:

Final technical rept. Jan 72-Nov 74,

Corporate Author:

MASSACHUSETTS GENERAL HOSPITAL BOSTON

Personal Author(s):

Report Date:

1975-02-01

Pagination or Media Count:

131.0

Abstract:

The sorption and desorption behavior of various compounds into and out of human skin was studied using an invitro technique. Aqueous solutions of radioactively tagged electrolytes were applied to the surface of intact specimens of epidermis and the sorption and desorption of these solutes by the stratum corneum was measured. Analysis of the equilibrium sorption data gave diffusion constants, values of partition coefficients and thermodynamic quantities, e.g. enthalpies of sorption. Water, alcohols, glycols, phenos, esters and assorted other nonelectrolytes were studied. The sorption of water was found to have a large effect on the structure of the stratum corneum leading to increased sorption capacity and greater diffusivity of the tissue for other subsequently applied substances.

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE