Enzyme Immobilization Alternatives for the Enzyme Alarm.
Quarterly rept. Oct 74-Jan 75,
LEEDS AND NORTHRUP CO NORTH WALES PA
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The research concerns the study of alternative processes for coupling the cholinesterase enzyme to various supports in order to achieve enzyme-support products which can be produced in large quantities, stored and then provide at least 12 hours of reliable operation after deployment. Since prior work has emphasized physical entrapment of the enzyme as means of immobilization, this project is oriented primarily to chemical bonding and cross-linking processes. The highest enzyme activity derivatives achieved to date are cholinesterase attached to glass beads by azo coupling and glutaraldehyde cross-linking. Although the measured activities are high, their thermal stabilities are unacceptable.
- Physical Chemistry
- Chemical, Biological and Radiological Warfare