Cisternal Drainage, Ventriculo-Aqueductal Perfusion Techniques, and Their Application in Research Related to Brain Chemistry.
Special pub. Oct 71-Jun 73,
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
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Studies of brain physiology can be separated into two categories first, those in which the internal milieu of the brain is altered and the effects of this alteration on neural function observed and, second, those studies in which brain function is altered and a change in brain chemistry is the dependent variable. The former paradigm represents the application of exogenous materials to brain and the latter, the collection of endogenous materials from brain. The ventricular system, bounded by the inner surface of many important brain structures, represents an ideal means to gain access to these structures and thereby study in a nondestructive fashion progressive changes in local brain chemistry as a function of pharmacological or physiological manipulation. This paper, therefore, describes the techniques of ventricular perfusion, ventricular injection, and chronic sampling of ventricular fluid in several species with special effort to provide all information necessary to carry out the procedure.
- Anatomy and Physiology