Accession Number:

ADA009718

Title:

Acute Systemic Toxicity of Pure Dimercaprol and Trimercaptopropane.

Descriptive Note:

Technical rept. Aug-Oct 57,

Corporate Author:

EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s):

Report Date:

1975-05-01

Pagination or Media Count:

11.0

Abstract:

The presence of 1,2,3-trimercaptopropane in dimercaprol 2,3-dimercapto-1-propanol, British anti-lewisite is the cause of significant variations in reported toxicity values of dimercaprol. When injected intramuscularly in rats and mice, trimercaptone-free dimercaprol is approximately one-fifth as toxic as toxic as an equivalent amount of trimercaptopropane. No synergistic effects between the two compounds were found.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE