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Correlation of Cardiac Performance, Ultrastructural Morphology and Mitochondrial Function in Endotoxemia in the Dog.
OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
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The role of myocardial deterioration in the pathogensis of endotoxin septic shock is under serious consideration in both basic and clinical reports. The present collaborative study was devised to join together the expertise of several laboratories in the evaluation and correlation of cardiac performance, myocardial mitochondrial activity and ultrastructural morphology in the canine heart response to lethal endotoxin administration. Studies were conducted on adult animals in which both intack and isolated hearts were studied 4-7 hours post-endotoxin. Results demonstrated cardiac failure evidenced by markedly elevated left ventricular end diastolic pressure, while mitochondrial oxidative metabolism and energy production capacities, as measured in isolated mitochondria, were within normal ranges. Ultrastructural studies carried out on separate animals during the same time period after endotoxin revealed minimal mitochondrial edema formation together with moderate swelling of T-tubular structures.
APPROVED FOR PUBLIC RELEASE