Studies Relative to Antigenicity of Plasma Volume Expanders.
Final rept. 1 Oct 66-30 Jun 72,
JEFFERSON MEDICAL COLL PHILADELPHIA PA
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The immunogenicity of a number of proposed plasma expanders of both natural and synthetic origin were studied in experimental animals such as rabbits, guinea pigs, mice and sheep and eventually some of these were studied in man. Although different techniques for immunization were employed to study immunogenicity in the above various species, the following summary statements can be made. The hydroxyethyl starch preparations were immunogenic in the species studied. The homopolymer, PAMEG, gamma-2-N ethyl morpholino derivative of polyglutamic acid although immunogenic in rabbits, was not immunogenic in man. The introduction of propanolamine groupings onto the carboxyl groups in the polymers, polyglutamic acid, polyglutamic acid alanine and polyglutamic acid tyrosine, also resulted in preparations that were considerably less immunogenic than the same random polymers of amino acids without the modification. It was determined that the nature of the determinants in the responses against PAMEG were related to N-ethylmorpholine, and the nature of the determinants against GAT amide or GA amide were related to the propanolamide determinants.
- Medicine and Medical Research