Immunity to Malaria Parasites.
Final technical rept. Aug 73-Sep 74,
GLASGOW UNIV (SCOTLAND) DEPT OF ZOOLOGY
Pagination or Media Count:
It is proposed that a knowledge of the basic mechanisms involved in immunity to malaria parasites and of the evasive reactions which some malaria parasites are known to take subsequently will be assistance in the development of an antimalarial vaccine. Immunity to the blood stages of Plasmodium falciparum in man and of P. berghei berghei and P. vinckei chabaudi in mice has been investigated. Plasmodium falciparum taken from infected Gambian infants was grown through 2-12 cycles in microtissue culture trays. Under optimal conditions multiplication rates of up to 6x were recorded after the first phase of schizogeny and reinvasion. In the microculture system relatively few immune Gambian sera reduced the reinvasion rate of P. falciparum. In the rodent malarias phagocytosis, promoted by opsonizing antibody, of red cells containing mature trophozoites or schizonts was observed. Immunity to P.v. chabaudi in C57BL mice could be transferred with serum or cells. By transferring cells to 600 rad irradiated mice, the protective effect of relatively few immune spleen cells could be demonstrated. In immunization studies the protection induced in mice by inoculating irradiated P.b. berghei parasitized red cells was enhanced by Bordetella pertussis and in one experiment by BCG.
- Medicine and Medical Research