Studies of Regeneration of Mammalian Skeletal Muscle.
Final technical rept. Apr 73-Jan 75,
BRISTOL UNIV (ENGLAND) DEPT OF PHYSIOLOGY
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The report details the results of experiments designed to measure physiological characteristics of regenerating rat muscle. Twitch time to peak and time to half relaxation, the ratio of twitch to tetanic tension and the rate of development of tetanic tension were measured in isometric contractions and compared with the changes of normal postnatal development. Recovery was assessed objectively by estimating maximum tetanic tension at various times after transplantation and again compared with normal development. The main series involved mincing the transplanted muscle in six week old animals. The rate of regeneration up to 100 days 3.1 gday was compared with that in muscle which had been denervated before transplantation or held at a short length by a plaster limb cast 2.0 gday. Regeneration was also slower in adult rats 1.6 gday. Nerve regeneration was examined and found to reach a maximum rate by 10 days.
- Anatomy and Physiology