Accession Number:

ADA007214

Title:

Drug Therapy of Acute Pulmonary Insufficiency

Descriptive Note:

Technical Report,01 Apr 1971,31 Mar 1974

Corporate Author:

PENNSYLVANIA UNIV PHILADELPHIA PHILADELPHIA United States

Personal Author(s):

Report Date:

1975-03-15

Pagination or Media Count:

59.0

Abstract:

The oral or parenteral administration of eriodictyol prevented the appearance of signs of acute pulmonary insufficiency provoked by the following procedures inhalation of 25 carbon dioxide in oxygen by mice, intraperitoneal injection of paraquat in rats, intravenous injection of endotoxin in rats and intravenous infusion of iodoacetamide in monkeys. Benzoylcarbinolmorpholineacetate hydrochloride Mobecarbe is effective in preventing pulmonary lesions induced by inhalation of carbon dioxide in mice. This compound prevented as well as reversed the pulmonary lesions provoked by endotoxin in rats, and by hemorrhagic shock and dextran infusion in monkeys.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE