The Effect of Treatment with Whole Bee Venom on Cage Activity and Plasma Cortisol Levels in the Arthritic Dog.
Technical rept. Mar 71-Oct 73,
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
Pagination or Media Count:
Sixteen normal and eight arthritic dogs of several breeds were used to study the effects of whole bee venom on canine arthritis. Cage activity, measured by a pedometer, and plasma cortisol levels were monitored. In the first phase of this study, half of the normal dogs and half of the arthritic dogs were given 1 mg of whole bee venom subcutaneously in the second phase, the other half were given the venom. In each phase, four injections of the venom were given from 1 to 2 weeks apart, and the responses of the untreated and treated animals were compared. Results showed that the venom increased plasma cortisol levels in all groups but increased cage activity only in the arthritic dogs. Thirty days after the last injection, plasma cortisol levels had returned to normal, but cage activity in the arthritic dogs remained significantly above baseline levels.