Accession Number:

ADA003611

Title:

Frozen Blood Cell Changes.

Descriptive Note:

Final rept. 1 Sep 69-30 Nov 74,

Corporate Author:

CENTER FOR BLOOD RESEARCH BOSTON MASS

Personal Author(s):

Report Date:

1975-01-15

Pagination or Media Count:

9.0

Abstract:

Several fundamental characteristics of human red cells, bone marrow, and peripheral blood granulocytes have been elucidated, which have led to enhancement of knowledge concerning blood cell preservation and senescence of red cells. The accumulation of calcium ion from plasma in red cells aging in vivo or in blood bags, results in non-deformable cells subject to splenic sequestration. Red cell viability depends on prevention of calcium ion entry and accumulation. The application of electronic cell sizing makes possible the rapid evaluation of bone marrow and peripheral blood leukocytes. Techniques developed for use in pursuit of research for this contract are invaluable as they permit rapid and simple assessment of cell quality affording means to optimize preservation and yielding viable post-thawed cells.

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE