Physiology and Metabolism of 'Neisseria gonorrhoeae'.
Final rept. 1 Apr 73-30 Jun 74,
HARVARD SCHOOL OF PUBLIC HEALTH BOSTON MASS DEPT OF MICROBIOLOGY
Pagination or Media Count:
Studies which have examined various aspects of the physiology and metabolism of Neisseria gonorrhoeae are reported. The principal findings are 1 Glucose is dissimilated by a combination of the Entner-Doudoroff and pentose phosphate pathways. 2 The dissimilation of glucose is an aerobic process no growth occurs under anaerobic conditions. 3 Growth temperature markedly affects the dissimilation of glucose. 4 Glucose-limited cultures are susceptible to autolysis nitrogen limited cultures are not. 5 Glucosamine enhances autolysis in glucose-depleted cultures. 6 N. gonorrhoeae and N. meningitidis are susceptible to growth inhibition by the gonadal steroid progesterone. The site of inhibition appears to be located in the cytoplasmic membrane.