Accession Number:

ADA002797

Title:

Nature and Control of Side-Reactions Due to Diethylcarbamazine in the Treatment of Malayan Filariasis.

Descriptive Note:

Final rept. 27 Jul 73-26 Jul 74,

Corporate Author:

SEOUL NATIONAL UNIV (REPUBLIC OF KOREA) DEPT OF PARASITOLOGY

Personal Author(s):

• Seo,Byong-Seol

Report Date:

1974-10-21

Pagination or Media Count:

68.0

Abstract:

The chemotherapy against human filariasis has developed since Santiago-Stevenson 1947 had reported that 1-diethylcarbamyl-4-methyl-piperazine hydrochloride has an activity of the rapid disappearance of microfilaria from the peripheral blood. And many trials of mass treatment by this compound have ever been made by the investigators all over the world. However, because of the adverse reactions after drug administration, it is urgently necessitated to know the nature and control of these reactions, particularly in the treatment of malayan filariasis, in order to bring the successful results in the chemotherapeutic control measure of this nematodiasis. Studies on several dose schedules and the histopathology of adverse reactions are discussed.

Descriptors:

• *CHEMOTHERAPEUTIC AGENTS
• *FILARIASIS
• *ANTHELMINTICS
• DOSAGE
• PATHOLOGY
• RESPONSE(BIOLOGY)
• DRUGS
• SOUTH KOREA
• PARASITIC DISEASES
• TOXICOLOGY
• HELMINTHIC DISEASES

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE