Nature and Control of Side-Reactions Due to Diethylcarbamazine in the Treatment of Malayan Filariasis.
Final rept. 27 Jul 73-26 Jul 74,
SEOUL NATIONAL UNIV (REPUBLIC OF KOREA) DEPT OF PARASITOLOGY
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The chemotherapy against human filariasis has developed since Santiago-Stevenson 1947 had reported that 1-diethylcarbamyl-4-methyl-piperazine hydrochloride has an activity of the rapid disappearance of microfilaria from the peripheral blood. And many trials of mass treatment by this compound have ever been made by the investigators all over the world. However, because of the adverse reactions after drug administration, it is urgently necessitated to know the nature and control of these reactions, particularly in the treatment of malayan filariasis, in order to bring the successful results in the chemotherapeutic control measure of this nematodiasis. Studies on several dose schedules and the histopathology of adverse reactions are discussed.