The Interrelationship of Cholinoreceptors with Histamine and Serotonin in Gastric Mucosa during Secretion.
ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER CHARLOTTESVILLE VA
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Secretory responses to stimulants acting through a cholinoreceptor were studied in chronic tests conducted on dogs with a gastric fistula. Intravenous infusion of carbacholine tended to greatly heighten the histamine and serotonin concentration in the gastric juice. A drop of the level of these amines in the animal tissues by the administration of reserpine for many days resulted in sharply diminishing secretory responses to carbacholine and insulin whereas an exogenous introduction of histamine and serotonin continued to produce an effect. The inference was made that acetylcholine in the gastric mucosa causes secretion by mediation through biogenic amines as the direct effect on the secretory cells and are liberated with stimulation of cholinoreceptors.